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KMID : 1189420050180010061
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2005 Volume.18 No. 1 p.61 ~ p.70
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Influences on Immune Function of Allergic Rat induced by Ovalbumin of Onweetang(OWT)
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Han Jin-Geun
Kim Jong-Han
Park Su-Yeon
Choi Jung-Hwa
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Abstract
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Objective: This study was performed to investigate the effects of OWT on allergic bronchial asthma.
Methods: The mice were divided into 4 groups induced the allergic bronchial asthma : Three groups(OWT-1, OWT-2, OWT-3) treated OWT and non-treated group(Control). Three oral administration of the herbal solution of OWT were carried out 1 lime a day for 2 weeks before antigen sensitization. 2 days later, the mice were sensitized with a subcutaneous injection of ovalbumin(OA) and then 13 days later they were provoked with OA aerosols. Then the cell numbers in bronchoalveolar lavage fluid(BALF), serum level of IgE, WBC, RBC and HCB were measured.
Results: 1. On the neutrophil in BALF, OWT-1 group is significantly increased compared with the control group. 2. On the eosinophil in BALF, OWT-1 group tends to decrease compared with the control group but insignificant. 3. On the lymphocyte in BALF, OWT-2 group is significantly decreased compared with the control group. 4. On the macrophage in BALF, OWT-2 group is significantly increased compared with the control group. 5. On the serum IgE, groups OWT-1, OWT-2 and OWT-3 are significantly decreased compared with the control group. 6. On WBC in blood, OWT-1 group is significantly decreased compared with the control group.
Conclusions: Based on the above results, it is assumed that the oral administration of OWT can help the treatment of allergic bronchial asthma.
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KEYWORD
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Onweetang(OWT), Allergicbronchialasthma
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